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Accelrys pipeline pilot v8.0
Pipeline Pilot V8.0, supplied by Accelrys, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pipeline+pilot+v8%2E0/pipeline+pilot+version+7+5/pm34971401-212-22-25
Average 90 stars, based on 1 article reviews
pipeline pilot v8.0 - by Bioz Stars, 2026-10
90/100 stars

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Functional Assay:

Article Title: Tox-GAN: An Artificial Intelligence Approach Alternative to Animal Studies-A Case Study With Toxicogenomics.
Article Snippet: Animal studies are a critical component in biomedical research, pharmaceutical product development, and regulatory submissions.. There is a worldwide effort in toxicology toward “reducing, refining, and replacing” animal use.. Here, we proposed a deep generative adversarial network (GAN)-based framework capable of deriving new animal results from existing animal studies without additional experiments.

Article Title: Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.
Article Snippet: Many flavonoids and isoflavonoids have an undesirable bitter taste, which hampers their use as food bioactives.. The aim of this study was to investigate the effect of a large set of structurally similar (iso)flavonoids on the activation of bitter receptors hTAS2R14 and hTAS2R39 and to predict their structural requirements to activate these receptors.. In total, 68 compounds activated hTAS2R14 and 70 compounds activated hTAS2R39, among which 58 ligands were overlapping.

Article Title: In vitro to in vivo extrapolation for drug-induced liver injury using a pair ranking method.
Article Snippet: Specifically, the well-established functional class fingerprints (FCFPs) with a radius of FCFP 4 were used as chemical descriptors to calculate Tanimoto coefficients between two compounds (Hassan et al., 2006), which were implemented in Pipeline Pilot v8.0 (Accelrys, Biovia, and Dassault Systems). from Brainarray3 and applied FARMS (Hochreiter et al., 2006) for summarizing the intensity ratios at probe set level to obtain expression values per gene.

Article Title: Application of RNAi to Genomic Drug Target Validation in Schistosomes
Article Snippet: In order to obtain some ideas about the potential targets that the DDU set may be targeted a multi categorical Laplacian-modified naïve Bayesian model, as described by Nidhi et al. [ ] with ChEMBL version 6 as training set [ ], using Pipeline Pilot v8.0 (Biovia) was built.

Article Title: Application of RNAi to Genomic Drug Target Validation in Schistosomes.
Article Snippet: Predicted target assignment for the DDU set In order to obtain some ideas about the potential targets that the DDU set may be targeted a multi categorical Laplacian-modified naïve Bayesian model, as described by Nidhi et al. [52] with ChEMBL version 6 as training set [53], using Pipeline Pilot v8.0 (Biovia) was built.

Article Title: Protein Kinase C Inhibitors Sensitize GNAQ Mutant Uveal Melanoma Cells to Ionizing Radiation
Article Snippet: Images were analyzed for γH2AX intensity using custom algorithms developed with the Pipeline Pilot (v8.0) software platform (Accelrys, San Diego, CA, USA) in a similar workflow as previously described.

Expressing:

Article Title: Tox-GAN: An Artificial Intelligence Approach Alternative to Animal Studies-A Case Study With Toxicogenomics.
Article Snippet: Animal studies are a critical component in biomedical research, pharmaceutical product development, and regulatory submissions.. There is a worldwide effort in toxicology toward “reducing, refining, and replacing” animal use.. Here, we proposed a deep generative adversarial network (GAN)-based framework capable of deriving new animal results from existing animal studies without additional experiments.

Article Title: Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.
Article Snippet: Many flavonoids and isoflavonoids have an undesirable bitter taste, which hampers their use as food bioactives.. The aim of this study was to investigate the effect of a large set of structurally similar (iso)flavonoids on the activation of bitter receptors hTAS2R14 and hTAS2R39 and to predict their structural requirements to activate these receptors.. In total, 68 compounds activated hTAS2R14 and 70 compounds activated hTAS2R39, among which 58 ligands were overlapping.

Article Title: In vitro to in vivo extrapolation for drug-induced liver injury using a pair ranking method.
Article Snippet: Specifically, the well-established functional class fingerprints (FCFPs) with a radius of FCFP 4 were used as chemical descriptors to calculate Tanimoto coefficients between two compounds (Hassan et al., 2006), which were implemented in Pipeline Pilot v8.0 (Accelrys, Biovia, and Dassault Systems). from Brainarray3 and applied FARMS (Hochreiter et al., 2006) for summarizing the intensity ratios at probe set level to obtain expression values per gene.

Article Title: Application of RNAi to Genomic Drug Target Validation in Schistosomes
Article Snippet: In order to obtain some ideas about the potential targets that the DDU set may be targeted a multi categorical Laplacian-modified naïve Bayesian model, as described by Nidhi et al. [ ] with ChEMBL version 6 as training set [ ], using Pipeline Pilot v8.0 (Biovia) was built.

Article Title: Application of RNAi to Genomic Drug Target Validation in Schistosomes.
Article Snippet: Predicted target assignment for the DDU set In order to obtain some ideas about the potential targets that the DDU set may be targeted a multi categorical Laplacian-modified naïve Bayesian model, as described by Nidhi et al. [52] with ChEMBL version 6 as training set [53], using Pipeline Pilot v8.0 (Biovia) was built.

Article Title: Protein Kinase C Inhibitors Sensitize GNAQ Mutant Uveal Melanoma Cells to Ionizing Radiation
Article Snippet: Images were analyzed for γH2AX intensity using custom algorithms developed with the Pipeline Pilot (v8.0) software platform (Accelrys, San Diego, CA, USA) in a similar workflow as previously described.



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